Applications brief: Functionalized metal-organic framework nanocomposites fordispersive solid phase extraction and enantioselective capture of chiral drug intermediates

Key results


  • A novel MGO-ZnCB sorbent for dispersive SPE was presented and characterized using AFM-IR
  • The results showed fast and efficient capture of BN and Furion entantiomers

Key words

Chiral drug intermediates | dispersive magnetic nanoparticle solid phase extraction (d-MNSPE) | enantioselective capture | graphene | metal organic frameworks | nanocomposites

Authors

X. Ma, X. Zhou, A. Yu, W. Zhao, W. Zhang, S. Zhang, L. Wei, D. Cook, A. Roy

Abstract

The facile preparation, characterization and application of a novel magnetic graphene oxide- metalorganic framework [Zn2(d-Cam)2(4, 4’-bpy)]n (MGO-ZnCB) as a sorbent for fast, simple and enantioselective capture of chiral drug intermediates are presented in this paper. The MGO-ZnCB nanocomposite, developed by encapsulating MGO nanoparticles into the homochiral metal organic framework of ZnCB, can integrate the advantages from each component endowing the hybrids with improved synergistic effects. The enantioselective performance of MGO-ZnCB was evaluated by dispersive magnetic nanoparticle solid phase extraction (d-MNSPE) of 1, 1’-bi-2-naphthol (BN) and 2, 2’-furoin (Furoin) racemic solutions. Due to the excellent dispersive capability, high stability, relatively larger saturation magnetiza-tion and distinct enrichment capacity of MGO-ZnCB, the d-MNSPE method provides good enantioselective separation of these compounds with enantiomeric excess (ee) values as high as 74.8% and 57.4%, respectively. The entire process with BN or Furoin can be completed within 3 min or less. After washing with methanol, the host MGO-ZnCB can be easily recycled and reused six times without any apparent loss of performance. Furthermore, the adsorbed BN and Furoin in nanodomains of the MGO-ZnCB composite were directly investigated for the first time by atomic force microscopy-infrared (AFM-IR) technique.


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Using AFM-IR, the adsorbed BN and Furoin on MGO-ZnCB composite of nanodomains were directly investigated for the first time. Image (a) shows a microtomed thin film of the MGO-ZnCB in which a rhombic particle can be seen. In images (b) and (c), the spatial distribution of the components on the particle can be seen, with the highlighted region showing lower IR absorption at 1594 cm-1 than at 1382 cm-1, suggesting that this distribution was not homogenous.
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