- This study looked into the capabilities of lipid-based films in biotechnology based on certain structures and properties
- PTIR was used to analyze distribution of paclitaxel, a drug usually difficult to encapsulate and release, in a multilayered lipid-polymer hybrid film with nanostructure
- It was found that the self-assembled film composition was altered substantially when introduced to paclitaxel, and was able to capture the drug
Lipid films | lipid-polymer hybrids | solid-state NMR | substrate-mediated delivery | supported membranes
M. Kang, M. Tuteja, A. Centrone, D. Topgaard, C. Leal
Amphiphilic in nature, lipids spontaneously self-assemble into a range of nanostructures in the presence of water. Among lipid self-assembled structures, liposomes and supported lipid bilayers have long held scientific interest for their main applications in drug delivery and plasma membrane models, respectively. In contrast, lipid-based multilayered membranes on solid supports only recently begin drawing scientists’ attention. Current studies show that the stacking of multiple bilayers on a solid support yields cooperative structural and dynamic behavior that enables new functionalities. Lipid films provide compartmentalization, templating, and enhanced release of molecules of interest. Importantly, supported lipid phases exhibit long-range periodic nanoscale order and orientation that is tunable in response to a changing environment. Herein, the current understanding of lipid-based film research is summarized focusing on how unique structural characteristics enable the emergence of new applications including label-free biosensors, macroscale drug delivery, and substrate-mediated gene delivery. The authors’ recent contributions focusing on the structural characterization of lipid-based films using small-angle X-ray scattering and atomic force microscopy are highlighted. In addition, new photothermally induced resonance and solid-state nuclear magnetic resonance data are described, providing insights into drug partition in lipid-based films as well as structure and dynamics at the molecular scale.